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KMID : 0613820130230121553
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Journal of Life Science
2013 Volume.23 No. 12 p.1553 ~ p.1556
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Effects of Citrus sunki Peel Extract on Matrix Metalloproteinase-1 Expression
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Han Gu-Seul
Lee Sun-Ryung
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Abstract
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Flavonoids are one of the major components found in the peels of citrus fruits. Present evidence has suggested that polymethoxyflavonoids, including nobiletin and tangeretin isolated from Citrus sunki, have many biological properties, such as anti-inflammatory, anti-oxidant, and anti-obesity capabilities. Here, we investigated the effect of Citrus sunki peel extract and its possible mechanisms on oxidative stress-induced MMP-1 expression, a major marker of skin photoaging. H₂O₂ induced MMP-1 expression in a dose- and time-dependent manner. Extract of Citrus sunki peel (1-25 μg/ml) dose-dependently decreased MMP-1 mRNA levels. When H₂O₂ was combined with Citrus sunki peel extract, the phosphorylation of ERK was further decreased compared to a single treatment with H₂O₂ alone. Moreover, U0216, an MEK inhibitor, markedly prevented the production of MMP-1. These data suggest that Citrus sunki peel extract has demonstrated protective activity against oxidative damage on MMP-1 expression, and ERK MAP kinase may be involved.
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KEYWORD
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Citrus sunki, matrix metalloproteinase-1, oxidative stress, skin aging
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